Search results for abx831201

Olaratumab, Abbexa, abx831201

Olaratumab is a monoclonal antibody biosimilar expressed in CHO cells, targeting PDGFRA/PDGFR2/CD140a, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Studies show that the treatment of olaratumab in combination with doxorubicin resulted in significant reduction of cancer cell proliferation and tumor growth. Olaratumab was granted accelerated approval (as Lartruvo) as initial therapy to treat adults with certain types of soft tissue sarcoma (STS) in October, 2016.