Search results for abx831462

Cibisatamab, Abbexa, abx831462

Cibisatamab is a monoclonal antibody biosimilar expressed in CHO cells, targeting CD3E/CEACAM5, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Cibisatamab (CEA-TCB) is a T cell bispecific antibody that binds carcinoembryonic antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab has a single CD3ε chain binding site and two CEA binding sites on T cells (it regulates the binding affinity to cancer cells with high expression of CEA on the cell surface). This avoids targeting healthy epithelial cells with low CEA expression levels. T cell activation, cytokine secretion and release of cytotoxic particles are triggered by binding to CEA on the surface of cancer cells and CD3 on T cells.