Search results for cyclin D1 (CCND1) Antibody
Cyclin D1 (CCND1) Antibody, Abbexa, abx034749
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx011703
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Host
Mouse
Reactivity
Human
Applications
ELISA
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx224352
CCND1 Antibody is a Mouse Monoclonal against CCND1.
Host
Mouse
Reactivity
Human
Applications
ELISA, IF/ICC, FCM
Conjugation
Cyclin D1 (CCND1) Antibody, Abbexa, abx214742
CCND1 Antibody is a Rabbit Polyclonal against CCND1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx125624
CCND1 Antibody is a Rabbit Polyclonal against CCND1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, IP
Conjugation
Unconjugated
cyclin D1 (CCND1) Antibody, Abbexa, abx432565
cyclin D1 Antibody is a Goat Polyclonal antibody against cyclin D1.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx330261
CCND1 Antibody is a Rabbit Polyclonal against CCND1.
Host
Rabbit
Reactivity
Mouse, Rat
Applications
WB, IHC
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx140376
Cyclin D1 Antibody is a Mouse Monoclonal against Cyclin D1.
Host
Mouse
Reactivity
Human, Monkey, Mouse, Rat
Applications
WB, IHC, IF/ICC, FCM, IP
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx100480
Polyclonal Antibody to Cyclin D1 (CCND1).
Host
Rabbit
Reactivity
Chicken
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cyclin D1 (CCND1) Antibody, Abbexa, abx117083
CCND1 Antibody is a Rabbit Polyclonal antibody against CCND1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, IP
Conjugation
Unconjugated
Please provide the required information below so that we can quickly source your products.