Search results for histone-lysine N-methyltransferase

Histone-lysine N-methyltransferase PRDM9 antibody, Covalab, Ref 00014144

Histone-lysine N-methyltransferase (MLL5) antibody, Covalab, Ref 00013893

Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody, Abbexa, abx026519

Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly (ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function; rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage.

Histone-lysine N-methyltransferase EZH2 (EZH2) Antibody, Abbexa, abx402120

Histone-lysine N-methyltransferase EZH2 (EZH2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human EZH2.

Histone-Lysine N-Methyltransferase SETD7 (SETD7) Antibody, Abbexa, abx456667

Histone-Lysine N-Methyltransferase SETD7 (SETD7) Antibody is a Rabbit polyclonal antibody for the detection of Human Histone-Lysine N-Methyltransferase SETD7 (SETD7).

Histone-Lysine N-Methyltransferase EZH2 (EZH2) Antibody, Abbexa, abx215269

Histone-Lysine N-Methyltransferase EZH2 (EZH2) Antibody is a Rabbit Polyclonal antibody for the detection of EZH2.

Histone-lysine N-methyltransferase EZH2 (EZH2) Antibody, Abbexa, abx402519

Histone-lysine N-methyltransferase EZH2 (EZH2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human EZH2.

Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody, Abbexa, abx026518

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Histone-Lysine N-Methyltransferase SETDB1 (SETDB1) Antibody, Abbexa, abx456125

Histone-Lysine N-Methyltransferase SETDB1 (SETDB1) Antibody is a Rabbit polyclonal antibody for the detection of Human Histone-Lysine N-Methyltransferase SETDB1 (SETDB1).

Histone-Lysine N-Methyltransferase SETMAR (SETMAR) Antibody, Abbexa, abx237773

SETMAR Antibody is a Rabbit Polyclonal against SETMAR.