Search results for methyl-CpG binding domain protein 1
Methyl-CpG-binding domain protein 1 (MBD1) Antibody, Abbexa, abx402402
Methyl-CpG-binding domain protein 1 (MBD1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human MBD1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Methyl-Cpg-Binding Domain Protein 1 (MBD1) Antibody, Abbexa, abx457392
Methyl-Cpg-Binding Domain Protein 1 (MBD1) Antibody is a Rabbit polyclonal antibody for the detection of Human Methyl-Cpg-Binding Domain Protein 1 (MBD1).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Methyl CpG Binding Domain Protein 1 (MBD1) Antibody, Abbexa, abx037541
Rabbit Polyclonal against the MBD1 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 1 (MBD1) Antibody, Abbexa, abx025689
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD) (1). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA (2). MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases (3). In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract (4).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 1 (MBD1) Antibody, Abbexa, abx333879
MBD1 Antibody is a Rabbit Polyclonal against MBD1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Methyl CpG Binding Domain Protein 1 (MBD1) Antibody, Abbexa, abx037542
Rabbit Polyclonal against the MBD1 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 1 (MBD1) Antibody (FITC), Abbexa, abx336523
MBD1 Antibody (FITC) is a Rabbit Polyclonal against MBD1.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
Methyl-CpG Binding Domain Protein 1 (MBD1) Antibody (HRP), Abbexa, abx336522
MBD1 Antibody (HRP) is a Rabbit Polyclonal against MBD1.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
Methyl-CpG Binding Domain Protein 1 (MBD1) Antibody (Biotin), Abbexa, abx336524
MBD1 Antibody (Biotin) is a Rabbit Polyclonal against MBD1.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Human Methyl-CpG-binding domain protein 1 (MBD1) ELISA Kit, Abbkine, KTE61704
• Do not mix components from different kit lots or use reagents beyond the kit expiration date.• Allow all reagents to warm to room temperature for at least 30 minutes before opening.• Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. • Unused wells must be kept desiccated at 4 °C in the sealed bag provided.• Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.• It is recommended that all samples and standards be assayed in duplicate or triplicate.
Host
Reactivity
Applications
Conjugation
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