Search results for protein kinase CHK2
Serine/Threonine-Protein Kinase Chk2 (CHEK2) Antibody, Abbexa, abx377127
Serine/Threonine-Protein Kinase Chk2 (CHEK2) Antibody is a Rabbit polyclonal antibody for the detection of Human Serine/Threonine-Protein Kinase Chk2 (CHEK2).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase Chk2 (CHK2) Antibody, Abbexa, abx010556
CHK2: CHK2 checkpoint homolog (S. pombe). In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase Chk2 (CHK2) Antibody, Abbexa, abx231654
Chk2 Antibody is a Rabbit Polyclonal against Chk2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase Chk2 (CHK2) Antibody, Abbexa, abx012850
Rabbit polyclonal antibody against Chk2 protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Serine/Threonine-Protein Kinase CHK2 Phospho-Thr383 (CHEK2 pT383) Antibody, Abbexa, abx012469
Rabbit polyclonal antibody against Chk2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:T383, M:T387, R:T386.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
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Chk2 (1C12) Mouse Monoclonal Antibody (BSA and Azide Free)#17332, Cell Signaling Technology (CST), 17332
Chk2 (1C12) Mouse Monoclonal Antibody (BSA and Azide Free) detects endogenous levels of total Chk2 protein.
Host
Mouse
Reactivity
Human, Monkey
Applications
Conjugation
Chk2 (1C12) Mouse Monoclonal Antibody#3440, Cell Signaling Technology (CST), 3440
Chk2 (1C12) Mouse Monoclonal Antibody detects endogenous levels of total Chk2 protein.
Host
Mouse
Reactivity
Human, Monkey
Applications
Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:3200 Immunofluorescence (Immunocytochemistry): 1:200
Conjugation
Chk2 Antibody#2662, Cell Signaling Technology (CST), 2662
Chk2 Antibody detects endogenous levels of total Chk2 protein independent of phosphorylation.
Host
Reactivity
Human, Mouse, Rat, Monkey
Applications
Western Blotting: 1:1000 Immunoprecipitation: 1:50
Conjugation
Chk2 (D9C6) Rabbit Monoclonal Antibody#6334, Cell Signaling Technology (CST), 6334
Chk2 (D9C6) Rabbit Monoclonal Antibody recognizes endogenous levels of total Chk2 protein.
Host
Rabbit
Reactivity
Human
Applications
Western Blotting: 1:1000 Simple Western<sup>TM</sup>: 1:10 - 1:50 Immunoprecipitation: 1:100
Conjugation
Phospho-Chk2 (Ser19) Antibody#2666, Cell Signaling Technology (CST), 2666
Phospho-Chk2 (Ser19) Antibody detects endogenous levels of Chk2 only when phosphorylated at serine 19. This antibody does not cross-react with Chk2 phosphorylated at other sites.
Host
Reactivity
Human
Applications
Western Blotting: 1:1000
Conjugation
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