Search results for splicing factor proline and glutamine rich
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx000914
SFPQ Antibody is a Rabbit Polyclonal antibody against SFPQ. SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. Catalog# 15585-1-AP is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx027680
DNA-and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Transcriptional repression is probably mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx237785
SFPQ Antibody is a Rabbit Polyclonal against SFPQ.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Splicing Factor, Proline- And Glutamine-Rich (SFPQ) Antibody, Abbexa, abx433672
Splicing Factor, Proline- And Glutamine-Rich (SFPQ) Antibody is a Goat Polyclonal against Splicing Factor, Proline- And Glutamine-Rich (SFPQ).
Host
Goat
Reactivity
Human
Applications
P-ELISA, IHC
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx115801
Splicing Factor Proline/Glutamine-Rich (Polypyrimidine Tract Binding Protein Associated) Antibody is a Rabbit Polyclonal antibody against Splicing Factor Proline/Glutamine-Rich (Polypyrimidine Tract Binding Protein Associated).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx376219
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody is a Rabbit Polyclonal antibody against Splicing Factor Proline And Glutamine Rich (SFPQ).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody, Abbexa, abx338782
SFPQ Antibody is a Rabbit Polyclonal against SFPQ.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody (HRP), Abbexa, abx337802
SFPQ Antibody (HRP) is a Rabbit Polyclonal against SFPQ.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody (Biotin), Abbexa, abx337804
SFPQ Antibody (Biotin) is a Rabbit Polyclonal against SFPQ.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody (FITC), Abbexa, abx337803
SFPQ Antibody (FITC) is a Rabbit Polyclonal against SFPQ.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
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