Search results for IGF1R

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx172913

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody is a Mouse Monoclonal antibody against Insulin Like Growth Factor 1 Receptor (IGF1R).

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx000628

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody is a Rabbit Polyclonal antibody against Insulin Like Growth Factor 1 Receptor (IGF1R). Insulin Like Growth Factor 1 Receptor (IGF1R), also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. Insulin Like Growth Factor 1 Receptor (IGF1R) binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, Insulin Like Growth Factor 1 Receptor (IGF1R) binds IGF1. The hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long and hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in Insulin Like Growth Factor 1 Receptor (IGF1R) may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance). The antibody is specific to Insulin Like Growth Factor 1 Receptor (IGF1R).

Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx461427

Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human IGF1R.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx033572

The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

Phospho-INSR-Y1150/IGF1R-Y1135 Rabbit pAb- ABclonal, ABclonal, AP0044

Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx421242

Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibody is a Human Monoclonal antibody for the detection of Insulin-Like Growth Factor 1 Receptor (IGF1R) in Human samples.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx327744

IGF1R Antibody is a Rabbit Polyclonal against IGF1R.

Insulin-like growth factor 1 receptor (IGF1R) Antibody, Abbexa, abx349924

Insulin-like growth factor 1 receptor (IGF1R) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human IGF1R.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx328731

IGF1R Antibody is a Rabbit Polyclonal against IGF1R.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody, Abbexa, abx016028

IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines.Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs.The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation.Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation.Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151.Full kinase activation requires the triple tyrosine phosphorylation.