Search results for B4

Ephrin Receptor B4 Antibody (YA2892), MedChemexpress, HY-P83147

Ephrin Receptor B4 Antibody (YA2892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin Receptor B4.

EPH Receptor B4 (EPHB4) Antibody, Abbexa, abx326139

EPHB4 Antibody is a Rabbit Polyclonal against EPHB4.

Lipoxin B4 (LXB4) ELISA Kit, Abbexa, abx519913

Lipoxin B4 (LXB4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Lipoxin B4 concentrations in serum, plasma and other biological fluids.

Leukotriene B4 (LTB4) ELISA Kit, Abbexa, abx257172

Leukotriene B4 (LTB4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Leukotriene B4 (LTB4) concentrations in serum, plasma, tissue homogenates and other biological fluids.

Homeobox B4 (HOXB4) Antibody (FITC), Abbexa, abx336022

HOXB4 Antibody (FITC) is a Rabbit Polyclonal against HOXB4.

Anti-TNP Monoclonal Antibody (IGEL b4), ProteoGenix, ARO-A23229

Ephrin B4, Mouse, mAb VEB4-7E4, Hycult Biotech, HM1099

The monoclonal antibody VEB4-7E4 recognizes mouse Ephrin type-B receptor 4 (EphB4), an ~110 kD protein. Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell-extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo’s, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well. The monoclonal antibody VEB4-7E4 marks venous endothelial cells, but not arterial endothelial cells in B16 melanoma cells.

GEF-H1, Human, mAb B4/7, Hycult Biotech, HM2152

The monoclonal antibody B4/7 recognizes human and canine guanine nucleotide exchange factor H1 (GEF-H1). GEFH1 is an ~110 kDa protein belonging to the Dbl family of proto-oncogenes. GEF-H1 can activate the small GTPase RhoA, but not Rac1 or Cdc42. Rho family GTPases are central regulators of epithelial tight junctions and the cytoskeleton. GEF-H1 can associate with different cytoskeletal structures, namely microtubules and the actin cytoskeleton. It has also been proposed to mediate crosstalk between the two types of filaments. Localization of GEF-H1 differs between cell types. In MRC-5 fibroblast cells, GEF-H1 localizes to stress fibers. In epithelial cells, GEF-H1 is associated with apical tight junctions and involved in regulating paracellular permeability of small hydrophilic tracers. Furthermore, its subcellular localization changes in mitotic cells, where endogenous GEF-H1 is concentrated at mitotic spindles. GEF-H1 is capable of binding to the F-actin binding junctional adaptor cingulin. Binding to cingulin inhibits GEF-H1 and results in the downregulation of RhoA and inhibition of G1/S phase transition. In low confluent cultured cells, the localization of GEF-H1 is predominantly cytoplasmic. With increasing density of the cells, free GEF-H1 is sequestered at the tight junctions by cingulin. GEF-H1 is part of the signaling pathway connecting epithelial polarity with the cell cycle, and as such involved in oncogenesis.

Melanoma-Associated Antigen B4 (MAGEB4) Antibody, Abbexa, abx113664

Melanoma Antigen Family B, 4 Antibody is a Rabbit Polyclonal antibody against Melanoma Antigen Family B, 4.

Anti-GEF H1 antibody [B4/7], Abcam, AB90783