Search results for PD-L1

PD-L1/CD274 Rabbit pAb- ABclonal, ABclonal, A11273

Anti-PD-L1 antibody [28-8], Abcam, AB205921

Anti-PD-L1 antibody [28-8] (ab205921) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB, mIHC in human samples. Anti-PD-L1 antibody [28-8] (ab205921) has been cited over 476 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-PD-L1 antibody [28-8] (ab205921) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PD-L1 antibody [28-8] (ab205921) has been confirmed by testing in knockout samples. Anti-PD-L1 antibody [28-8] (ab205921) has 13 independent reviews from customers. Anti-PD-L1 antibody [28-8] (ab205921) specifically detects PD-L1 (UniProt ID: Q9NZQ7; Molecular weight: 31kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (50 µL). Conjugation-ready, carrier free format available for antibody clone 28-8 - ab228413 . Antibody clone 28-8 is also available pre-conjugated to a variety of labels for your convenience - HRP, PE, Alexa Fluor® 555, Alexa Fluor® 568, Alexa Fluor® 594, FITC ( ab209961 , ab209962 , ab213358 , ab213359 , ab213360 , ab224027 ). PD-L1 (Programmed Death-Ligand 1) is a protein that plays a significant role in oncology, particularly in the immune response to cancer. It is expressed on the surface of cancer cells and interacts with the PD-1 receptor on T-cells, effectively inhibiting the immune system's ability to attack the tumor. This interaction is a key target for immunotherapy drugs, such as checkpoint inhibitors, which block the PD-1/PD-L1 pathway, allowing the immune system to recognize and destroy cancer cells. FURTHER INFORMATION ON POSITIVE CONTROLS ( Chinese version ) Tissue: - Tonsil - with hyperreactive changes. Screening of hyper-reactive tonsils is recommended to find tonsil with the highest expression of PD-L1 in crypt epithelium, macrophages homing the germinal centers and interfollicular mononuclear leukocytes. - Tumor tissues - prescreened for positive tumor and inflammatory infiltrates. PD-L1 expression varies by tumor type so screening is recommended to find positive and negative tumor controls. - The following publication is useful for finding suitable tumor types for PD-L1 expression: http://www.immunotherapyofcancer.org/content/1/S1/P53 - Note: Look for specimens with high numbers of inflammatory macrophages and mononuclear leukocytes. Cell Lines: - Positive controls: B-CPAP (high), ES-2 (medium), HCC70 (low). Primary antibody negative control: Recombinant Rabbit IgG isotype control antibody, ab172730 . Recombinant protein positive control: Recombinant human PD-L1 protein, ab167713 . Immunohistochemistry usage: For IHC usage on FFPE tissues, we recommend using PD-L1 IHC panel ab236676 , which contains PD-L1 antibody clone 28-8 (ab205921), HIER antigen retrieval reagent ( ab208572 ) and IHC detection kit HRP/DAB ( ab209101 ). Western blot usage: For clone 28-8, it is recommended to use Odyssey system. This system has the advantages of a wider dynamic range and less background than chemiluminescence. This PD-L1 antibody [28-8] has been used as detector antibody in Human PD-L1 SimpleStep ELISA ® kit: ab214565 and ab277712 . To support you in your biomarker discovery and validation studies, we offer a comprehensive suite of solutions including high quality, validated recombinant antibodies and assay kits. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-PD-L1 antibody [29E.2A3], Abcam, AB259283

Anti-PD-L1 antibody [73-10], Abcam, AB228415

Anti-PD-L1 antibody [73-10] (ab228415) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP and WB. Abcam's high quality manufacturing and validation processes ensure Anti-PD-L1 antibody [73-10] (ab228415) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PD-L1 antibody [73-10] (ab228415) has been confirmed by Western Blot testing in PD-L1 knockout A549 cells ( ab267054 ). Anti-PD-L1 antibody [73-10] (ab228415) specifically detects PD-L1 (UniProt ID: Q9NZQ7; Molecular weight: 32kDa) and is sold in 50 µL selling sizes. Conjugation-ready, carrier free format available for antibody clone 73-10 - ab226766 . Antibody clone 73-10 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, Alexa Fluor ® 555, Alexa Fluor ® 594 ( ab237402 , ab237403 , ab274896 , ab275355 ). Programmed death-ligand 1 (PD-L1) is a critical protein in immuno-oncology, playing a significant role in tumor immune evasion. It is expressed on the surface of tumor cells and binds to the PD-1 receptor on T cells, inhibiting their activity and allowing tumors to escape immune detection. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-PD-L1 antibody [EPR23546-160], Abcam, AB252436

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

HRP Anti-PD-L1 antibody [EPR19759], Abcam, AB215349

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-Human PD-L1 (IB6) Antibody, ichor.bio, ICH4018A-0.1mg

Detects human PD-L1.

PE Anti-PD-L1 antibody [10F.9G2], Abcam, AB210189

PE Anti-PD-L1 antibody [28-8], Abcam, AB209962

What is this antibody validated in? PE Anti-PD-L1 antibody [28-8] (ab209962) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt) in Human samples. Related products Antibody clone 28-8 is also available pre-conjugated to a variety of labels for your convenience – Anti-PD-L1 PE [28-8] (ab209962). Other related products We have a range of other formats of antibody clone [28-8] also available for your convenience: ab205921 , APC - ab206967 , Carrier free - ab209889 , Alexa Fluor® 488 - ab209959 , Alexa Fluor® 647 - ab209960 , HRP - ab209961 , PE - ab209962, Alexa Fluor® 555 - ab213358 , Alexa Fluor® 568 - ab213359 , Alexa Fluor® 594 - ab213360 , FITC - ab224027 , Carrier free - ab228413 , Carrier free - ab278010 , Alexa Fluor® 647 - ab303724, Carrier free - ab307495, Biotin - ab322788 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

PE Anti-PD-L1 antibody [29E.2A3], Abcam, AB270652