Search results for raf1
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx033702
RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC, FCM
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx329067
RAF1 Antibody is a Rabbit Polyclonal against RAF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx326544
RAF1 Antibody is a Rabbit Polyclonal against RAF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx012788
Rabbit polyclonal antibody against C-RAF protein. Immunogen region is C-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx327767
RAF1 Antibody is a Rabbit Polyclonal against RAF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx011435
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx329619
RAF1 Antibody is a Rabbit Polyclonal against RAF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
RAF Proto-Oncogene Serine/Threonine-Protein Kinase (RAF1) Antibody, Abbexa, abx377274
RAF Proto-Oncogene Serine/Threonine-Protein Kinase (RAF1) Antibody is a Rabbit polyclonal antibody for the detection of Human RAF Proto-Oncogene Serine/Threonine-Protein Kinase (RAF1).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx237088
RAF1 Antibody is a Rabbit Polyclonal against RAF1.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx218161
Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody is a Rabbit Polyclonal antibody for the detection of RAF1. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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