Search results for Protein kinase B
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx002172
BRAF Antibody is a Rabbit Polyclonal antibody against BRAF. BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109. Entrez Protein NP_004324. It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Serine/Threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx377730
Serine/Threonine-Protein Kinase B-Raf (BRAF) Antibody is a Rabbit polyclonal antibody for the detection of Human Serine/Threonine-Protein Kinase B-Raf (BRAF).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx006176
BRAF Antibody is a Rabbit Polyclonal Antibody against BRAF.
Host
Rabbit
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx302175
BRAF Antibody is a Rabbit Polyclonal against BRAF.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx033697
BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Serine/Threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx227130
Serine/Threonine-Protein Kinase B-Raf (BRAF) Antibody is a Rabbit Monoclonal antibody for the detection of B-raf.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC
Conjugation
Unconjugated
Serine/threonine-protein kinase B-raf (BRAF) Antibody, Abbexa, abx402052
Serine/threonine-protein kinase B-raf (BRAF) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human BRAF.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx010442
B-Raf is a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx015780
BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109.Entrez Protein NP_004324.It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway.B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439).B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region.Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras.Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers.The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers.
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx230941
BRAF Antibody is a Rabbit Polyclonal against BRAF.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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