Search results for Raf

Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx010442

B-Raf is a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.

Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx015780

BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109.Entrez Protein NP_004324.It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway.B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439).B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region.Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras.Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers.The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers.

Anti-Human BRAF/B-Raf (V600E) Antibody (SAA2068), AntibodySystem, RHD08202

Anti-Human BRAF/B-Raf (V600E) Antibody (SAA2181), AntibodySystem, RHD08203

Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody, Abbexa, abx230941

BRAF Antibody is a Rabbit Polyclonal against BRAF.

Anti-Phospho-BRAF/B-Raf (Thr401) Antibody (R1P57), AntibodySystem, RHD08204

Phospho-B-Raf (Ser365) (F6P2S) Rabbit Monoclonal Antibody#61231, Cell Signaling Technology (CST), 61231

Phospho-B-Raf (Ser365) (F6P2S) Rabbit Monoclonal Antibody recognizes endogenous levels of B-Raf protein only when phosphorylated at Ser365. This antibody does not cross-react with B-Raf phosphorylated at Ser363, Ser364, or Ser446, or c-Raf phosphorylated at Ser259. This antibody detects a 70 kDa protein of unknown identity in some cell lines.

Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody (HRP), Abbexa, abx314761

BRAF Antibody (HRP) is a Rabbit Polyclonal against BRAF conjugated to HRP.

Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody, Abbexa, abx213794

RAF1 Antibody is a Rabbit Polyclonal against RAF1.

Mouse Serine/threonine-protein kinase A-Raf (ARAF) ELISA Kit, Abbexa, abx502228

Mouse Serine/threonine-protein kinase A-Raf (ARAF) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Serine/threonine-protein kinase A-Raf concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.