Search results for receptor
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx011486
ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.
Host
Mouse
Reactivity
Human
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) Antibody, Abbexa, abx146445
ROR2 Antibody is a Rabbit Polyclonal against ROR2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) Antibody, Abbexa, abx033603
ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx033601
ROR1 is a receptor protein tyrosine kinase whose cellular role has not been determined. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Studies of a similar protein in mouse suggest that this protein may interact with another receptor protein tyrosine kinase and may be involved in skeletal and cardiac development.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) Antibody, Abbexa, abx328028
ROR2 Antibody is a Rabbit Polyclonal against ROR2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) Antibody, Abbexa, abx004297
ROR2 Antibody is a Rabbit Polyclonal antibody against ROR2. The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx449254
ROR1 Antibody is a Rabbit Polyclonal Antibody against ROR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx002361
ROR1 Antibody is a Rabbit Polyclonal antibody against ROR1. This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Host
Rabbit
Reactivity
Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx033600
ROR1 is a receptor protein tyrosine kinase whose cellular role has not been determined. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Studies of a similar protein in mouse suggest that this protein may interact with another receptor protein tyrosine kinase and may be involved in skeletal and cardiac development.
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, WB, FCM
Conjugation
Unconjugated
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody, Abbexa, abx104447
Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1).
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
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