Search results for tyrosine kinase
Tyrosine Kinase Non Receptor 1 (TNK1) Antibody, Abbexa, abx012267
TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Host
Mouse
Reactivity
Human
Applications
ELISA
Conjugation
Unconjugated
PTK2 Protein Tyrosine Kinase 2 (FAK) Antibody, Abbexa, abx015852
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents.The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents.This cellular localization is directed by a Focal Adhesion Targeting (FAT) sequence, a 125 amino acid sequence at the C-terminus.FAK plays an important role in migration, cell spreading, differentiation, cytoskeleton protein phosphorylation, apoptosis and acceleration of the G1 to S phase transition of the cell cycle.It associates with several different signaling proteins such as Src-family PTKs, p130Cas, Shc, Grb2, PI 3-kinase, and paxillin.This enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways.FAK is also linked to oncogenes at biochemical and functional levels.Increased expression and/or activity of FAK in various tumors has been correlated with enhanced migration and invasiveness of human tumor cells in addition to promoting increased cell proliferation.
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Protein Tyrosine Kinase 2 Beta (PTK2) Antibody, Abbexa, abx126434
PTK2 Antibody is a Rabbit Polyclonal against PTK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF/ICC
Conjugation
Unconjugated
Rat Bruton'S Tyrosine Kinase (Btk) ELISA Kit, Abbexa, abx155273
Rat Bruton'S Tyrosine Kinase (Btk) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Bruton'S Tyrosine Kinase (Btk) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Bruton'S Tyrosine Kinase (Btk)No significant cross-reactivity or interference between Bruton'S Tyrosine Kinase (Btk) and analogues was observed.
Host
Reactivity
Rat
Applications
ELISA
Conjugation
Tyrosine Kinase, Non-Receptor, 1 (TNK1) Antibody, Abbexa, abx116390
Tyrosine Kinase, Non-Receptor, 1 Antibody is a Rabbit Polyclonal antibody against Tyrosine Kinase, Non-Receptor, 1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Human Spleen tyrosine kinase (SYK) ELISA Kit, Abbkine, KTE60410
• Do not mix components from different kit lots or use reagents beyond the kit expiration date.• Allow all reagents to warm to room temperature for at least 30 minutes before opening.• Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. • Unused wells must be kept desiccated at 4 °C in the sealed bag provided.• Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.• It is recommended that all samples and standards be assayed in duplicate or triplicate.
Host
Reactivity
Applications
Conjugation
Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Antibody, Abbexa, abx328566
NTRK2 Antibody is a Rabbit Polyclonal against NTRK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
BMX Non Receptor Tyrosine Kinase (BMX) Antibody, Abbexa, abx129068
BMX Non Receptor Tyrosine Kinase Antibody is a Rabbit Polyclonal against BMX Non Receptor Tyrosine Kinase.
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Spleen Associated Tyrosine Kinase (SYK) Antibody (Biotin), Abbexa, abx338151
SYK Antibody (Biotin) is a Rabbit Polyclonal against SYK.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx033588
MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation. MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
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