Search results for TP53

Cellular Tumor Antigen P53 (TP53) Antibody, Abbexa, abx422676

Cellular Tumor Antigen P53 (TP53) Antibody is a Mouse monoclonal against Cellular Tumor Antigen P53 (TP53).

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx137497

Cellular Tumor Antigen p53 (p53) Antibody is a E. coli Monoclonal antibody against Cellular Tumor Antigen p53 (p53).

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx034680

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx139924

p53 Antibody is a Mouse Monoclonal against p53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx330036

TP53 Antibody is a Rabbit Polyclonal against TP53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx327408

TP53 Antibody is a Rabbit Polyclonal against TP53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx032761

Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx402146

Cellular Tumor Antigen p53 (TP53) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human TP53.

Anti-Human TP53/p53 Antibody (163.6#), AntibodySystem, RHC10005

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx421875

Cellular Tumor Antigen p53 (TP53) Antibody is a Mouse Monoclonal antibody for the detection of Cellular Tumor Antigen p53 (TP53) in Human samples.