Search results for db
TSC2 (pS1387) Antibody, Abbexa, abx031950
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC, DB
Conjugation
Unconjugated
RAC-Beta Serine/Threonine-Protein Kinase Phospho-Ser474 (AKT2 pS474) Antibody, Abbexa, abx031949
AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Amyloid Fibrils (OC) Antibody (ATTO594), Abbexa, abx448317
Amyloid Fibrils (OC) Antibody (ATTO594) is a Rabbit Polyclonal against Amyloid.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC, IP, DB
Conjugation
ATTO594
JMJD2B (pS566) Antibody, Abbexa, abx032109
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
TSC1 (pT390) Antibody, Abbexa, abx032282
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Amyloid Fibrils (OC) Antibody (HRP), Abbexa, abx448383
Amyloid Fibrils (OC) Antibody (HRP) is a Rabbit Polyclonal against Amyloid.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC, IP, DB
Conjugation
HRP
ATF2 (pS322) Antibody, Abbexa, abx031961
ATF2 is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Bad (pS99) Antibody, Abbexa, abx031833
Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X (L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC, DB
Conjugation
Unconjugated
MAP3K7 (pT187) Antibody, Abbexa, abx031943
MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
APG8b (MAP1LC3B) (pT93 / Y99) Antibody, Abbexa, abx032094
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
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