Search results for homolog
Chromobox Homolog 2 (CBX2) Antibody, Abbexa, abx146269
CBX2 Antibody is a Rabbit Polyclonal against CBX2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Protein Scribble Homolog (SCRIB) Antibody, Abbexa, abx376254
Protein Scribble Homolog (SCRIB) Antibody is a Rabbit Polyclonal antibody against Protein Scribble Homolog (SCRIB).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Roundabout Homolog 4 (ROBO4) Antibody, Abbexa, abx321166
ROBO4 Antibody is a Rabbit Polyclonal against ROBO4.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Pygopus Homolog 2 (PYGO2) Antibody, Abbexa, abx376017
Pygopus Homolog 2 (PYGO2) Antibody is a Rabbit Polyclonal antibody against Pygopus Homolog 2 (PYGO2).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Adrenocortical Dysplasia Homolog (ACD) Antibody, Abbexa, abx125486
ACD Antibody is a Rabbit Polyclonal against ACD.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Denticleless Protein Homolog (DTL) Antibody, Abbexa, abx240101
Denticleless Protein Homolog (DTL) Antibody is a Rabbit Polyclonal antibody for the detection of DTL. Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX (DTL) complex, also named CRL4 (CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21 (CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21 (CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX (DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX (DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Denticleless Protein Homolog (DTL) Antibody, Abbexa, abx301818
DTL Antibody is a Rabbit Polyclonal against DTL.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Chromobox Homolog 5 (CBX5) Antibody, Abbexa, abx224232
CBX5 Antibody is a Mouse Monoclonal against CBX5.
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Roundabout Homolog 2 (ROBO2) Antibody, Abbexa, abx322653
ROBO2 Antibody is a Rabbit Polyclonal against ROBO2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Frizzled Homolog 2 (FZD2) Antibody, Abbexa, abx214482
FZD2 Antibody is a Rabbit Polyclonal against FZD2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
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