Search results for A2
Anti-CoV-RBD (A2) antibody, ProteoGenix, PTXCOV-A521D
Description of Anti-CoV-RBD (A2) antibody General information on Anti-CoV-RBD (A2) antibody The anti-CoV-RBD (A2) antibody is a fully human IgG immunoglobulin designed to target the receptor-binding domain (RBD) of the new pandemic strain of coronavirus, SARS-CoV-2. Targeting this specific domain presents unique advantages when it comes to the development of COVID-19 therapeutic antibodies. The RBD is responsible for recognizing and binding the specific cell surface marker ACE2 (angiotensin-converting enzyme 2). This interaction further leads to the proteolytic cleavage of the spike exposing the S2 subunit and initiating the formation of the membrane fusion core complex. Antibodies able to block this initial interaction are known as neutralizing antibodies (NAbs). These specific and rare antibodies are on the vanguard of COVID-19 treatments due to their ability to arrest SARS-CoV-2 infections in their earliest stages. This new antibody was obtained by screening a high-diversity COVID-19 human antibody library (LiAb-SFCOVID-19™) using phage display technology (i.e. biopanning) and recombinantly expressed RBD as the desired target. It capitalizes on the immune repertoire developed in patients who have been infected with COVID-19. Additionally, the specificity and affinity of the newly developed molecule were tested in the ELISA platform. Its stability and ease of production were further confirmed by consistently obtaining high production yields in XtenCHO™, a transient mammalian system based on an engineered variant of CHO. Moreover, the neutralizing activity of antibody R3P2-A2 was confirmed in vitro through the indirect detection assay: SARS-CoV-2 Surrogate Virus Neutralization kit. The assay works on the principle of direct competition between candidate antibodies and the ACE2 for the binding pocket of RBD. This antibody and other similar products serve as effective research tools to either detect the presence of SARS-CoV-2 in multiple samples in ELISA tests, as well as to potentially better understand the mechanism of infection in the new coronavirus.
Host
Reactivity
Applications
Conjugation
Carboxypeptidase A2, Pancreatic (CPA2) Antibody, Abbexa, abx242086
CPA2 Antibody is a Rabbit Polyclonal against CPA2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
EPH Receptor A2 (EPHA2) Antibody, Abbexa, abx010721
EPH Receptor A2 (EPHA2) Antibody is a Rabbit Polyclonal antibody for the detection of EPHA2. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Annexin A2 Receptor (ANXA2R) Antibody, Abbexa, abx339257
ANXA2R Antibody is a Rabbit Polyclonal against ANXA2R.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
LRG, Human, mAb 2F5.A2, Hycult Biotech, HM2013
The monoclonal antibody recognizes leucine-rich alpha-2-glycoprotein (LRG), a member of the leucine-rich repeat family. LRG is a plasma protein of approximately 50 kDa. LRG consists of 312 amino acids. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312 amino acids, and LRG contains at least eight 24-amino acid leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells. The monoclonal antibody 2F5.A2 can be used for immuno purification of human LRG.
Host
Human
Reactivity
Applications
Conjugation
HLA-A2 Antibody (Azide free), Abbexa, abx140225
HLA-A2 Antibody (Azide free) is a Mouse Monoclonal against HLA-A2.
Host
Mouse
Reactivity
Human
Applications
FCM, IP
Conjugation
Unconjugated
Protein S100-A2 (S100A2) Antibody, Abbexa, abx403847
Human Protein S100-A2 (S100A2) Antibody is a Mouse monoclonal against Protein S100-A2 (S100A2).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Carboxypeptidase A2, Pancreatic (CPA2) Antibody, Abbexa, abx171562
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Carboxypeptidase A2, Pancreatic (CPA2) Antibody is a Mouse Monoclonal antibody against Carboxypeptidase A2, Pancreatic (CPA2).
Host
Mouse
Reactivity
Rat
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Annexin A2 (ANXA2) Antibody (Biotin), Abbexa, abx272214
Annexin A2 (ANXA2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Annexin A2 (ANXA2).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Biotin
Annexin A2 (ANXA2) Antibody (HRP), Abbexa, abx303059
ANXA2 Antibody (HRP) is a Rabbit Polyclonal against ANXA2 conjugated to HRP.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
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