Search results for histone deacetylase A
Histone Deacetylase 6 (HDAC6) Antibody, Abbexa, abx140898
Histone Deacetylase 6 (HDAC6) Antibody is a Mouse Monoclonal against Histone Deacetylase 6 (HDAC6).
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Histone Deacetylase 9 (HDAC9) Antibody, Abbexa, abx001277
HDAC9 Antibody is a Rabbit Polyclonal antibody against HDAC9. In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1–9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Histone Deacetylase 3 (HDAC3) Antibody, Abbexa, abx015752
HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2.Entrez Protein NC_000005.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family.It has histone deacetylase activity and represses transcription when tethered to a promoter.It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1.This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.This gene is regarded as a potential tumor suppressor gene.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Histone Deacetylase 6 (HDAC6) Antibody, Abbexa, abx037705
Rabbit Polyclonal against the HDAC6 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Histone deacetylase 1 (HDAC1) Antibody, Abbexa, abx402244
Histone deacetylase 1 (HDAC1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human HDAC1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Histone Deacetylase 4 (HDAC4) Antibody, Abbexa, abx129913
Histone Deacetylase 4 Antibody is a Rabbit Polyclonal against Histone Deacetylase 4.
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Histone Deacetylase 3 (HDAC3) Antibody, Abbexa, abx159527
HDAC3 Antibody is a Mouse Monoclonal against HDAC3.
Host
Mouse
Reactivity
Human, Mouse, Rat, Dog, Pig, Rabbit
Applications
ELISA, WB
Conjugation
Unconjugated
Histone Deacetylase 1 (HDAC1) Antibody, Abbexa, abx026042
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Histone Deacetylase 3 (HDAC3) Antibody, Abbexa, abx010931
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Histone Deacetylase 10 (HDAC10) Antibody, Abbexa, abx026088
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2, 3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDAC8 interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv (16) (p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate to convert RUNX1 into a constitutive transcriptional repressor.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
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