Search results for FGFR3 antibody

Anti-FGFR3 antibody, Abcam, AB10651

Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides (MW 17-38 kD) that are potent physiological regulators of growth and differentiation for a wide variety of cells of mesodermal, ectodermal and endodermal origin. FGFs are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodelling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. The FGF family consists of at least seventeen members designated FGF1 through FGF17. To date, four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1 [flg-1(fms-like gene 1)]; FGFR2 [bek (bacterial expressed kinase gene product)]; FGFR3 (cek-2) and by alternative splicing have been reported. Soluble, secreted or possibly cleaved forms of FGFR-1 and FGFR-2 have also been found in body fluids or were artificially constructed. An example is a soluble FGF-binding protein containing the extracellular region of FGFR3 and the secreted form of placental alkaline phosphatase (FRAP3). FGFRs are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110-150 kD proteins consiting of an extracellular domain, a single transmembrane region and a cytoplasmic split tyrosine kinase domain, which is activated following ligand binding and receptor dimerization. The extracellular, ligand binding, region is constructed with either two (beta type) or typically three (alpha-type) immunoglobulin (Ig)-like domains, and an eight amino acid ‘acidic box’. The ligand binding site of all FGFRs is confined to the extracellular Ig-like domains 2 and 3. FGFRs exhibit overlapping recognition and redundant specificity. One receptor type may bind several of the FGFs with a similar affinity. Also, one FGF type may bind similarly to several distinct receptors. This accounts for the rather identical effects of different FGF ligands on common cell types. FGFs binding to cellular FGFRs depend on, or is markedly facilitated by the low-affinity interaction of FGFs with the polysaccharide component of cell surface or extracellular matrix heparan sulfate proteoglycans (HSPG). Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signalling molecules leads to DNA synthesis or differentiation. The signalling and biological responses elicited by distinct FGFRs substantially differ and are dictated by the intracellular domain. FGFR3 is widely expressed in many fetal and adult human and animal tissues. The FGFR3 expression profile largely correlates with its tissue specific expression at the mRNA level.

Anti-FGFR3 antibody [HL1595], Abcam, AB308173

What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

FGFR3 Antibody (YA3887)(PBS only), MedChemexpress, HY-P84190A

FGFR3 Antibody (YA3887) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FGFR3.

Anti-CD333/FGFR3 Antibody (R3G16), AntibodySystem, RHD52903

Anti-FGFR3 antibody - C-terminal, Abcam, AB180906

Anti-FGFR3 antibody [EPR2304(3)], Abcam, AB133644

What is this antibody validated in? Anti-FGFR3 antibody [EPR2304(3)] (ab133644) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB) in Human samples. What is the molecular weight of FGFR3? Anti-FGFR3 [EPR2304(3)] (ab133644) specifically detects a band for FGFR3 (UniProt: P22607) at a molecular weight of 88kDa. Trusted by the scientific community Anti-FGFR3 [EPR2304(3)] (ab133644) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-FGFR3 antibody [EPR2304(3)] (ab133644) has been confirmed by Immunocytochemistry testing in FGFR3 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR2304(3)] also available for your convenience: ab133644, Carrier free - ab187341 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-CD333/FGFR3 Antibody (R1S07), AntibodySystem, RHD52902

Anti-CD333/FGFR3 Antibody (R1S08), AntibodySystem, RHD52901

Fibroblast Growth Factor Receptor (FGFR3) Antibody, Abbexa, abx376667

Fibroblast Growth Factor Receptor (FGFR3) Antibody is a Rabbit polyclonal antibody for the detection of Mouse Fibroblast Growth Factor Receptor (FGFR3).

Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody, Abbexa, abx421939

Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody is a Mouse Monoclonal antibody for the detection of Fibroblast Growth Factor Receptor 3 (FGFR3) in Human samples.