Search results for GEF-H1

GEF H1 Antibody (YA1877), MedChemexpress, HY-P82132

GEF H1 Antibody (YA1877) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GEF H1.

Phospho-GEF H1 (Ser886) Antibody, Covalab, Ref 00120696

Human Rho Guanine Nucleotide Exchange Factor 2 / GEF-H1 / GEF-H1 (ARHGEF2) ELISA Kit, Abbexa, abx259593

Human Rho Guanine Nucleotide Exchange Factor 2 / GEF-H1 (ARHGEF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human GEF-H1 concentrations in tissue homogenates, cell lysates and other biological fluids.

GEF-H1, Human, mAb B4/7, Hycult Biotech, HM2152

The monoclonal antibody B4/7 recognizes human and canine guanine nucleotide exchange factor H1 (GEF-H1). GEFH1 is an ~110 kDa protein belonging to the Dbl family of proto-oncogenes. GEF-H1 can activate the small GTPase RhoA, but not Rac1 or Cdc42. Rho family GTPases are central regulators of epithelial tight junctions and the cytoskeleton. GEF-H1 can associate with different cytoskeletal structures, namely microtubules and the actin cytoskeleton. It has also been proposed to mediate crosstalk between the two types of filaments. Localization of GEF-H1 differs between cell types. In MRC-5 fibroblast cells, GEF-H1 localizes to stress fibers. In epithelial cells, GEF-H1 is associated with apical tight junctions and involved in regulating paracellular permeability of small hydrophilic tracers. Furthermore, its subcellular localization changes in mitotic cells, where endogenous GEF-H1 is concentrated at mitotic spindles. GEF-H1 is capable of binding to the F-actin binding junctional adaptor cingulin. Binding to cingulin inhibits GEF-H1 and results in the downregulation of RhoA and inhibition of G1/S phase transition. In low confluent cultured cells, the localization of GEF-H1 is predominantly cytoplasmic. With increasing density of the cells, free GEF-H1 is sequestered at the tight junctions by cingulin. GEF-H1 is part of the signaling pathway connecting epithelial polarity with the cell cycle, and as such involved in oncogenesis.

Anti-GEF H1 antibody [B4/7], Abcam, AB90783

Anti-GEF H1 (phospho S885) antibody, Abcam, AB74156

Anti-GEF H1 antibody [EPR17963] - C-terminal, Abcam, AB201687

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Rho Guanine Nucleotide Exchange Factor 2 / GEF-H1 (ARHGEF2) Antibody, Abbexa, abx327934

ARHGEF2 Antibody is a Rabbit Polyclonal against ARHGEF2.

Rho Guanine Nucleotide Exchange Factor 2 / GEF-H1 (ARHGEF2) Antibody, Abbexa, abx036567

Rabbit Polyclonal against the ARHGEF2 protein.

Rho Guanine Nucleotide Exchange Factor 2 / GEF-H1 (ARHGEF2) Antibody, Abbexa, abx233412

GEF-H1 Antibody is a Rabbit Polyclonal against GEF-H1.