Search results for MUSK antibody
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx033588
MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation. MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx002025
MUSK Antibody is a Rabbit Polyclonal antibody against MUSK. This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
Host
Rabbit
Reactivity
Mouse
Applications
WB
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx235442
MUSK Antibody is a Rabbit Polyclonal against MUSK.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx177636
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibody is a Rabbit Polyclonal antibody against Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx033587
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx214594
MUSK Antibody is a Rabbit Polyclonal against MUSK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx214595
MUSK Antibody is a Rabbit Polyclonal against MUSK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx033586
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx011206
MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx145978
MUSK Antibody is a Rabbit Polyclonal against MUSK.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
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