Search results for Mannose Receptor antibody

Mannose Receptor antibody [MR5D3] (PE), Genetex, GTX43154

Mannose Receptor antibody [MR5D3] (FITC), Genetex, GTX43682

Mannose Receptor antibody [MR5D3] (FITC), Genetex, GTX43683

Mannose Receptor antibody [MR5D3] (FITC), Genetex, GTX43684

Mannose Receptor antibody [MR5D3] (Biotin), Genetex, GTX43965

Mannose Receptor antibody [MR5D3] (Biotin), Genetex, GTX43966

Mannose Receptor antibody [15-2] (FITC), Genetex, GTX00491-06

Mannose Receptor antibody [15-2] (APC), Genetex, GTX00491-07

Mannose Receptor antibody [15-2] (PE), Genetex, GTX00491-08

Anti-Mannose Receptor antibody [15-2], Abcam, AB8918

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells.