Search results for Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx038195
Rabbit Polyclonal against the ERK2 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx132251
Extracellular Signal Regulated Kinase 2 (ERK2) Antibody is a Rabbit Polyclonal against Extracellular Signal Regulated Kinase 2 (ERK2).
Host
Rabbit
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx034783
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The the MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC) ; as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx033263
MAPK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx013451
Rabbit polyclonal antibody against p42 MAPK protein. Immunogen region is Internal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx430126
MAPK1 Antibody is a Goat Polyclonal antibody against MAPK1.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB, IF/ICC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx179066
Extracellular Signal Regulated Kinase 2 (ERK2) Antibody is a Rabbit polyclonal antibody against Human Extracellular Signal Regulated Kinase 2 (ERK2).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx126124
MAPK1 Antibody is a Rabbit Polyclonal against MAPK1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx132232
Extracellular Signal Regulated Kinase 2 (ERK2) Antibody is a Mouse Monoclonal against Extracellular Signal Regulated Kinase 2 (ERK2).
Host
Mouse
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody, Abbexa, abx000614
MAPK1 Antibody is a Rabbit Polyclonal antibody against MAPK1. This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
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