Search results for Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody, Abbexa, abx001162
MAPK9 Antibody is a Rabbit Polyclonal antibody against MAPK9. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody, Abbexa, abx329743
MAPK9 Antibody is a Rabbit Polyclonal against MAPK9.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody, Abbexa, abx033442
JNK2 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. It is inhibited by dual specificity phosphatases, such as DUSP1. The protein has been shown to bind to at least three scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2 and MAPK8IP3/JIP-3/JSAP1. These proteins also bind other components of the JNK signaling pathway.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody, Abbexa, abx103741
Polyclonal Antibody to Mitogen Activated Protein Kinase 9 (MAPK9).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody, Abbexa, abx145501
MAPK9 Antibody is a Rabbit Polyclonal against MAPK9.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody (Biotin), Abbexa, abx304459
MAPK9 Antibody (Biotin) is a Rabbit Polyclonal against MAPK9 conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody (HRP), Abbexa, abx304457
MAPK9 Antibody (HRP) is a Rabbit Polyclonal against MAPK9 conjugated to HRP.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
Mitogen-Activated Protein Kinase 9 / JNK2 (MAPK9) Antibody (FITC), Abbexa, abx304458
MAPK9 Antibody (FITC) is a Rabbit Polyclonal against MAPK9 conjugated to FITC.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
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