Search results for Tyrosine-protein kinase Lck
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx234727
LCK Antibody is a Mouse Monoclonal against LCK.
Host
Mouse
Reactivity
Human, rat
Applications
ELISA, WB
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx001789
LCK Antibody is a Rabbit Polyclonal antibody against LCK. This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx431381
LCK Antibody is a Goat Polyclonal antibody against LCK.
Host
Goat
Reactivity
Human, Rat, Pig
Applications
P-ELISA, WB
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (Lck) Antibody, Abbexa, abx139707
Lck Antibody is a Mouse Monoclonal against Lck.
Host
Mouse
Reactivity
Human
Applications
WB, IF/ICC, FCM, IP
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx034905
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR) linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. This antibody is supplied as crude ascites.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx109389
Tyrosine-protein kinase Lck Antibody is a Rabbit Polyclonal antibody against Tyrosine-protein kinase Lck.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC, IP
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx327749
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Proto-oncogene tyrosine-protein kinase LCK (LCK) Antibody (Biotin), Abbexa, abx106038
Tyrosine-protein kinase Lck Antibody (Biotin) is a Rabbit Polyclonal antibody against Tyrosine-protein kinase Lck conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Proto-oncogene tyrosine-protein kinase LCK (LCK) Antibody (FITC), Abbexa, abx107452
Tyrosine-protein kinase Lck Antibody (FITC) is a Rabbit Polyclonal antibody against Tyrosine-protein kinase Lck conjugated to FITC.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
Proto-oncogene tyrosine-protein kinase LCK (LCK) Antibody (HRP), Abbexa, abx108872
Tyrosine-protein kinase Lck Antibody (HRP) is a Rabbit Polyclonal antibody against Tyrosine-protein kinase Lck conjugated to HRP.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
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