Search results for thrombopoietin receptor

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx323336

MPL Antibody is a Rabbit Polyclonal against MPL.

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx011224

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Thrombopoietin Receptor / CD110 (MPL) Antibody (Biotin), Abbexa, abx312922

MPL Antibody (Biotin) is a Rabbit Polyclonal against MPL conjugated to Biotin.

Thrombopoietin Receptor Antibody (YA3994)(PBS only), MedChemexpress, HY-P84297A

Thrombopoietin Receptor Antibody (YA3994) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Thrombopoietin Receptor.

Thrombopoietin Receptor / CD110 (MPL) Antibody (FITC), Abbexa, abx312921

MPL Antibody (FITC) is a Rabbit Polyclonal against MPL conjugated to FITC.

Thrombopoietin Receptor / CD110 (MPL) Antibody (HRP), Abbexa, abx312920

Thrombopoietin Receptor / CD110 (MPL) Antibody (HRP) is a Rabbit Polyclonal against Thrombopoietin Receptor / CD110 (MPL) conjugated to HRP.

Human Thrombopoietin Receptor / CD110 (MPL) ELISA Kit, Abbexa, abx258949

Human Thrombopoietin Receptor / CD110 (MPL) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Thrombopoietin Receptor / CD110 (MPL) concentrations in tissue homogenates, cell lysates and other biological fluids.

Mouse Thrombopoietin Receptor / CD110 (MPL) ELISA Kit, Abbexa, abx550933

Mouse Thrombopoietin Receptor / CD110 (MPL) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Thrombopoietin Receptor / CD110 concentrations in tissue homogenates, cell lysates and other biological fluids.

Mouse Thrombopoietin Receptor antibody (Anti-TPOR) ELISA Kit, Abbexa, abx353110

Mouse Thrombopoietin Receptor antibody (TPOR-Ab) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Thrombopoietin Receptor antibody concentrations in serum, plasma and other biological fluids.

TPOR antibody [ARC2257], Genetex, GTX05100