Search results for tyrosine kinase

Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody, Abbexa, abx033586

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Spleen Associated Tyrosine Kinase (SYK) Antibody (FITC), Abbexa, abx338150

SYK Antibody (FITC) is a Rabbit Polyclonal against SYK.

Human Tyrosine Kinase 2 (TYK2) ELISA Kit, Abbexa, abx153417

Human Tyrosine Kinase 2 (TYK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Tyrosine Kinase 2 (TYK2) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Tyrosine Kinase 2 (TYK2)No significant cross-reactivity or interference between Tyrosine Kinase 2 (TYK2) and analogues was observed.

Protein Tyrosine Kinase 2 Beta (PTK2) Antibody, Abbexa, abx015853

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents.The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents.This cellular localization is directed by a Focal Adhesion Targeting (FAT) sequence, a 125 amino acid sequence at the C-terminus.FAK plays an important role in migration, cell spreading, differentiation, cytoskeleton protein phosphorylation, apoptosis and acceleration of the G1 to S phase transition of the cell cycle.It associates with several different signaling proteins such as Src-family PTKs, p130Cas, Shc, Grb2, PI 3-kinase, and paxillin.This enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways.FAK is also linked to oncogenes at biochemical and functional levels.Increased expression and/or activity of FAK in various tumors has been correlated with enhanced migration and invasiveness of human tumor cells in addition to promoting increased cell proliferation.

Protein Tyrosine Kinase 2 Beta (PTK2) Antibody, Abbexa, abx214309

PTK2 Antibody is a Rabbit Polyclonal against PTK2.

Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1) Antibody, Abbexa, abx323165

NTRK1 Antibody is a Rabbit Polyclonal against NTRK1.

Protein Tyrosine Kinase 2 Beta (PTK2b) Antibody, Abbexa, abx131468

Protein Tyrosine Kinase 2 Beta Antibody is a Rabbit Polyclonal against Protein Tyrosine Kinase 2 Beta.

Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1) Antibody, Abbexa, abx326702

NTRK1 Antibody is a Rabbit Polyclonal against NTRK1.

Protein Tyrosine Kinase 2 Beta (PTK2B) Antibody, Abbexa, abx242178

PTK2B Antibody is a Rabbit Polyclonal against PTK2B.

Receptor Tyrosine Kinase Antibody Sampler Kit#42344, Cell Signaling Technology (CST), 42344