Search results for A2

EPH Receptor A2 (EphA2) Antibody, Abbexa, abx033513

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

EPH Receptor A2 (EPHA2) Antibody, Abbexa, abx137439

EPH Receptor A2 (EPHA2) Antibody is a Mouse Monoclonal antibody against EPH Receptor A2 (EPHA2).

Cyclin A1/A2 Rabbit mAb, ABclonal, A2635

Cytosolic Phospholipase A2 (PLA2G4A) Antibody, Abbexa, abx329164

PLA2G4A Antibody is a Rabbit Polyclonal against PLA2G4A.

Cytosolic Phospholipase A2 (PLA2G4A) Antibody, Abbexa, abx000706

PLA2G4A Antibody is a Rabbit Polyclonal antibody against PLA2G4A. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Carboxypeptidase A2 (CPA2) Antibody (HRP), Abbexa, abx303479

CPA2 Antibody (HRP) is a Rabbit Polyclonal against CPA2 conjugated to HRP.

Apolipoprotein A2 Rabbit pAb- ABclonal, ABclonal, A14690

Phospholipase A2, Group Ivf Antibody, Abbexa, abx114483

Phospholipase A2, Group Ivf Antibody is a Rabbit Polyclonal antibody against Phospholipase A2, Group Ivf.

Anti-CyclinA1/A2 Antibody (R1R46), AntibodySystem, RHD38202

EPH Receptor A2 (EphA2) Antibody, Abbexa, abx010719

EPH receptor A2 (EphA2), with 976-amino acid protein (about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers.EphA2 may serve as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.