Search results for P53

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx402146

Cellular Tumor Antigen p53 (TP53) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human TP53.

Anti-Human TP53/p53 Antibody (163.6#), AntibodySystem, RHC10005

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx403200

Human Cellular Tumor Antigen p53 (TP53) Antibody is a Mouse monoclonal against Cellular Tumor Antigen p53 (TP53).

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx323268

TP53 Antibody is a Rabbit Polyclonal against TP53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx011309

p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx145422

TP53 Antibody is a Rabbit Polyclonal against TP53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx402336

Cellular Tumor Antigen p53 (TP53) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human TP53.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx137175

Cellular Tumor Antigen p53 (p53) Antibody is a Mouse Monoclonal antibody against Cellular Tumor Antigen p53 (p53).

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx004409

TP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.

Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx034680

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.