Search results for db
TSC2 (pS1420) Antibody, Abbexa, abx032002
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC, DB
Conjugation
Unconjugated
Microtubule-Associated Protein Tau (MAPT) Antibody (PE), Abbexa, abx450176
Microtubule-Associated Protein Tau (MAPT) Antibody (PE) is a Mouse Monoclonal against Microtubule-Associated Protein Tau (MAPT).
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IF/ICC, DB
Conjugation
PE
Platelet-Activating Factor Acetylhydrolase IB Subunit Beta (PAFAH1B2) Antibody, Abbexa, abx032115
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
MAP Kinase-Activated Protein Kinase 2 Phospho-Thr334 (MAPKAPK2 pT334) Antibody, Abbexa, abx031874
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, DB
Conjugation
Unconjugated
Microtubule-Associated Protein Tau (MAPT) Antibody (FITC), Abbexa, abx450172
Microtubule-Associated Protein Tau (MAPT) Antibody (FITC) is a Mouse Monoclonal against Microtubule-Associated Protein Tau (MAPT).
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IF/ICC, DB
Conjugation
FITC
ERBB2 (pT1172) Antibody, Abbexa, abx032145
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC, DB
Conjugation
Unconjugated
Nanog (pS285) Antibody, Abbexa, abx032059
NANOG is a Ttranscription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
TSC2 (pS1388) Antibody, Abbexa, abx032288
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
mouse KIT (pY719) Antibody, Abbexa, abx032174
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, DB
Conjugation
Unconjugated
IL6ST (pY905) Antibody, Abbexa, abx032064
IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
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