Search results for alpha-1
Alpha-1-antitrypsin, Human, mAb 2C1, Hycult Biotech, HM2289
The mouse monoclonal antibody clone 2C1 recognizes polymeric forms of human alpha-1-antitrypsin. Alpha-1-antitrypsin is the most abundant circulating protease inhibitor. Serpinopathies are conformational diseases characterized by the polymerization and intracellular retention of members of the serine protease inhibitor or serpin superfamily of proteins.1 The best known is a1-antitrypsin deficiency, with the most common severe deficiency allele being the Z mutation (Glu342Lys). The severe Z deficiency allele (Glu342Lys) causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. This causes neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. Clone 2C1 recognizes polymers formed by Z α1-antitrypsin in vivo. It also recognizes polymers formed by the Siiyama (Ser53Phe) and Brescia (Gly225Arg) mutants, and the novel His334Asp shutter domain mutant of a1-antitrypsin that is associated with prolonged neonatal jaundice in a 6-week-old boy. These data show that Z and shutter domain mutants form polymers with a shared epitope.
Host
Human
Reactivity
Applications
Conjugation
Alpha-1-antitrypsin, Human, mAb 3C11, Hycult Biotech, HM2358
Antibody clone 3C11 recognizes both the healthy monomeric form (M variant) and the disease associated polymeric forms (Z variants) of human alpha-1-antitrypsin with equal affinity. Alpha-1-antitrypsin is a member of the serine protease inhibitor (serpin) superfamily which are proteins known for their ability to inhibit proteases. It is the most abundant circulating protease inhibitor known. It mainly targets enzymes released by neutrophils, especially neutrophil elastase (NE) but also proteinase 3 (PR3) and Cathepsin G (CG). Serpinopathies are conformational diseases characterized by the polymerization and intracellular retention of members of the serpin superfamily. The best known is alpha-1 antitrypsin deficiency, with the most common severe deficiency allele being the Z mutation (Glu342Lys). This severe autosomal dominant disorder causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. Due to this accumulation of polymers in hepatocytes, blood alpha-1 trypsin levels will decrease leading to chronic uninhibited tissue breakdown. This causes the degradation especially of lung tissue which will eventually lead to pulmonary emphysema. In addition, accumulation of polymers in hepatocytes causes liver diseases such as neonatal hepatitis, cirrhosis, and hepatocellular carcinoma.
Host
Human
Reactivity
Applications
Conjugation
Alpha-1-Acid Glycoprotein (a1AGP) Antibody, Abbexa, abx130174
Alpha-1-Acid Glycoprotein Antibody is a Rabbit Polyclonal against Alpha-1-Acid Glycoprotein.
Host
Rabbit
Reactivity
Rat
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Defensin Alpha 1, Neutrophil (DEFa1) Antibody, Abbexa, abx129366
Defensin Alpha 1, Neutrophil Antibody is a Rabbit Polyclonal against Defensin Alpha 1, Neutrophil.
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Integrin Alpha 1 (ITGA1) Antibody (FITC), Abbexa, abx412780
Integrin Alpha 1 (ITGA1) Antibody (FITC) is a Mouse Monoclonal antibody against CD49a.
Host
Mouse
Reactivity
Human
Applications
FCM
Conjugation
FITC
Defensin Alpha 1, Neutrophil (DEFA1) Antibody, Abbexa, abx005247
DEFA1 Antibody is a Rabbit Polyclonal antibody against DEFA1. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Importin Subunit Alpha-1 (KPNa2) Antibody, Abbexa, abx405897
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Human Importin Subunit Alpha-1 (KPNa2) Antibody is a Mouse monoclonal against Importin Subunit Alpha-1 (KPNa2).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Defensin Alpha 1, Neutrophil (DEFa1) Antibody, Abbexa, abx102994
Polyclonal Antibody to Defensin Alpha 1, Neutrophil (DEFa1).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Catenin Alpha 1 (CTNNA1) Antibody (Biotin), Abbexa, abx317782
CTNNA1 Antibody (Biotin) is a Rabbit Polyclonal against CTNNA1 conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Importin Subunit Alpha-1 (KPNA2) Antibody, Abbexa, abx275172
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Importin Subunit Alpha-1 (KPNA2) Antibody is a Rabbit Monoclonal against Human KPNA2.
Host
Rabbit
Reactivity
Human
Applications
FCM
Conjugation
Unconjugated
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