Search results for db

PTEN (pY176) Antibody, Abbexa, abx032258

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Amyloid Fibrils (OC) Antibody (APC), Abbexa, abx448365

Amyloid Fibrils (OC) Antibody (APC) is a Rabbit Polyclonal against Amyloid.

Microtubule-Associated Protein Tau (MAPT) Antibody (Biotin), Abbexa, abx450190

Microtubule-Associated Protein Tau (MAPT) Antibody (Biotin) is a Mouse Monoclonal against Microtubule-Associated Protein Tau (MAPT).

TSC1 (pT310) Antibody, Abbexa, abx032265

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

Cdc25A (pS79) Antibody, Abbexa, abx032018

CDC25A is a member of the CDC25 family of phosphatases.CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division.CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.

AMOT (pY599) Antibody, Abbexa, abx032202

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Anti-Pan-Lactyl-lysine Antibody (m1Y06), AntibodySystem, RGY00031

Anti-Pan-Lactyl-lysine Antibody (m1Y08), AntibodySystem, RGY00034

Mouse TSC1 (pT310) Antibody, Abbexa, abx032227

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Phospho-Ser801 (MAP4K4 pS801) Antibody, Abbexa, abx031987

M4K4, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.