Search results for Lysine
Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody, Abbexa, abx026518
Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Human Lysine Acetyltransferase 5 (KAT5) ELISA Kit, Abbexa, abx388068
Human Lysine Acetyltransferase 5 (KAT5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human KAT5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Human
Applications
ELISA
Conjugation
Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody, Abbexa, abx026519
Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly (ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function; rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Putative Protein-Lysine Deacylase ABHD14B (ABHD14B) Antibody, Abbexa, abx110739
ABHD14B Antibody is a Rabbit Polyclonal antibody against ABHD14B.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Histone-Lysine N-Methyltransferase NSD3 (NSD3) Antibody, Abbexa, abx235863
NSD3 Antibody is a Rabbit Polyclonal against NSD3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Histone-lysine N-methyltransferase KMT5C (KMT5C) Antibody, Abbexa, abx346891
Histone-lysine N-methyltransferase KMT5C (KMT5C) Antibody is a Rabbit Polyclonal antibody for the detection of Human KMT5C.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Histone-Lysine N-Methyltransferase SUV39H2 (SUV39H2) Antibody, Abbexa, abx457114
Histone-Lysine N-Methyltransferase SUV39H2 (SUV39H2) Antibody is a Rabbit polyclonal antibody for the detection of Human Histone-Lysine N-Methyltransferase SUV39H2 (SUV39H2).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Histone-Lysine N-Methyltransferase EZH2 (EZH2) Antibody, Abbexa, abx232918
EZH2 Antibody is a Rabbit Polyclonal against EZH2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC, IP
Conjugation
Unconjugated
Rat Lysine Demethylase 8 (KDM8) ELISA Kit, Abbexa, abx529860
Rat Lysine Demethylase 8 (KDM8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Lysine-specific demethylase 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Rat
Applications
ELISA
Conjugation
Lysine-Specific Demethylase 4D (KDM4D) Antibody (FITC), Abbexa, abx317436
KDM4D Antibody (FITC) is a Rabbit Polyclonal against KDM4D conjugated to FITC.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
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