Search results for Cellular tumor antigen p53
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx004409
TP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IP
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx034680
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx137497
Cellular Tumor Antigen p53 (p53) Antibody is a E. coli Monoclonal antibody against Cellular Tumor Antigen p53 (p53).
Host
E. coli
Reactivity
Human
Applications
SDS-PAGE
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx018341
P53 Antibody is a Mouse Monoclonal antibody against P53.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Cellular Tumor Antigen P53 (TP53) Antibody, Abbexa, abx422676
Cellular Tumor Antigen P53 (TP53) Antibody is a Mouse monoclonal against Cellular Tumor Antigen P53 (TP53).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx174989
Tumor Protein p53 (TP53) Antibody is a Mouse Monoclonal antibody against Tumor Protein p53 (TP53).
Host
Mouse
Reactivity
Rat
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx349968
Cellular Tumor Antigen p53 (TP53) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human TP53.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx159710
Cellular Tumor Antigen P53 (TP53) Antibody is a Mouse monoclonal against Cellular Tumor Antigen P53 (TP53).
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen P53 (TP53) Antibody, Abbexa, abx422671
Cellular Tumor Antigen P53 (TP53) Antibody is a Rabbit monoclonal against Cellular Tumor Antigen P53 (TP53).
Host
Rabbit
Reactivity
Human
Applications
WB, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx034998
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
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