Search results for MBD3 antibody
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx113709
Methyl-Cpg Binding Domain Protein 3 Antibody is a Rabbit Polyclonal antibody against Methyl-Cpg Binding Domain Protein 3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx025698
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx027584
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody (Biotin), Abbexa, abx315313
MBD3 Antibody (Biotin) is a Rabbit Polyclonal against MBD3 conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody (FITC), Abbexa, abx315312
MBD3 Antibody (FITC) is a Rabbit Polyclonal against MBD3 conjugated to FITC.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody (HRP), Abbexa, abx315311
MBD3 Antibody (HRP) is a Rabbit Polyclonal against MBD3 conjugated to HRP.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
Please provide the required information below so that we can quickly source your products.