Search results for VHL Antibody
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody, Abbexa, abx126781
VHL Antibody is a Rabbit Polyclonal against VHL.
Host
Rabbit
Reactivity
Mouse, Rat
Applications
WB
Conjugation
Unconjugated
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody, Abbexa, abx137707
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Mouse Monoclonal antibody against Von Hippel-Lindau Disease Tumor Suppressor (VHL).
Host
Mouse
Reactivity
Human
Applications
Conjugation
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody, Abbexa, abx000699
VHL Antibody is a Rabbit Polyclonal antibody against VHL. The Von Hippel-Lindau (VHL) protein is a substrate recognition component of an E3 ubiquitin ligase complex containing elongin BC (TCEB1 and TCEB2), cullin 1 (CUL1), and RING-box protein 1 (RBX1) (1,2,3). VHL protein has been shown to exist as three distinct isoforms resulting from alternatively spliced transcript variants (4). Loss of VHL protein function results in a dominantly inherited familial cancer syndrome that manifests as angiomas of the retina, hemangioblastomas of the central nervous system, renal clear-cell carcinomas and pheochromocytomas (4). Under normoxic conditions, VHL directs the ubiquitylation and subsequent proteosomal degradation of the hypoxia inducible factor HIF alpha, maintaining very low levels of HIF alpha in the cell. Cellular exposure to hypoxic conditions, or loss of VHL protein function, results in increased HIF alpha protein levels and increased expression of HIF-induced gene products, many of which are angiogenesis factors such as vascular endothelial growth factor (VEGF). Thus, loss of VHL protein function is believed to contribute to the formation of highly vascular neoplasias (4). In addition to HIF alpha, VHL is known to regulate the ubiquitylation of several other proteins, including tat-binding protein 1 (TBP-1), the atypical protein kinase C lambda (aPKC), and two subunits of the multiprotein RNA Polymerase II complex (RPB1 and RPB7) (5,6,7,8). Interactions with elongin BC, RPB1, RPB7 and the pVHL-associated KRAB-A domain containing protein (VHLaK) suggest that VHL may also play a more direct role in transcriptional repression.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF/ICC
Conjugation
Unconjugated
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody, Abbexa, abx012353
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Rabbit Polyclonal antibody for the detection of VHL.
Host
Rabbit
Reactivity
Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody, Abbexa, abx137392
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Mouse Monoclonal antibody against Von Hippel-Lindau Disease Tumor Suppressor (VHL).
Host
Mouse
Reactivity
Human
Applications
Conjugation
Unconjugated
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin), Abbexa, abx431704
VHL Antibody is a Goat Polyclonal antibody against VHL.
Host
Goat
Reactivity
Human, Mouse, Rat
Applications
P-ELISA, WB
Conjugation
Biotin
![Anti-Von Hippel Lindau/VHL antibody [OTI1E1] - BSA and Azide free Brand Logo](https://file.buyantibody.com/public/brand/20260608/Abcam.jpg "Click to View Anti-Von Hippel Lindau/VHL antibody [OTI1E1] - BSA and Azide free Product Detail")
Anti-Von Hippel Lindau/VHL antibody [OTI1E1] - BSA and Azide free, Abcam, AB273655
ab273655 is the carrier free version of ab140989 . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Host
Mouse
Reactivity
Human
Applications
WB, IHC-P
Conjugation
Anti-Von Hippel Lindau/VHL antibody [EPR24354-128] - BSA and Azide free, Abcam, AB282120
ab282120 is the carrier-free version of ab270968 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human
Applications
WB
Conjugation
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