Search results for discoidin

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody, Abbexa, abx033583

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.

Discoidin Domain Receptor Family, Member 2 (DDR2) Antibody, Abbexa, abx128745

Discoidin Domain Receptor Family, Member 2 Antibody is a Rabbit Polyclonal against Discoidin Domain Receptor Family, Member 2.

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody, Abbexa, abx033305

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody, Abbexa, abx015156

Rabbit polyclonal antibody against DDR1 protein. Immunogen region is Internal.

Discoidin Domain Receptor Family, Member 2 (DDR2) Antibody, Abbexa, abx172136

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Discoidin Domain Receptor Family, Member 2 (DDR2) Antibody is a Mouse Monoclonal antibody against Discoidin Domain Receptor Family, Member 2 (DDR2).

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody, Abbexa, abx011452

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Three isoforms of this gene are generated by alternative splicing. [PROW].

Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Antibody, Abbexa, abx232291

DDR1 Antibody is a Rabbit Polyclonal against DDR1.

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody, Abbexa, abx146917

Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody is a Rabbit Polyclonal antibody for the detection of DDR1. Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Discoidin, CUB and LCCL domain-containing protein 2 antibody, Covalab, Ref 00036348

Discoidin Domain Receptor Family, Member 2 (DDR2) Antibody, Abbexa, abx325359

DDR2 Antibody is a Rabbit Polyclonal against DDR2.