Search results for CD40

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx412787

CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibody is a Rat Monoclonal antibody against CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40). The formulation of this antibody contains low levels of endotoxin.

Tecaginlimab Biosimilar – Anti-CD40 & CD137 mAb – Research Grade, ProteoGenix, PX-TA1777

Description of Tecaginlimab Biosimilar - Anti-CD40 & CD137 mAb - Research Grade Introduction Tecaginlimab Biosimilar, also known as Anti-CD40 & CD137 mAb, is a research grade antibody that has shown promising results in preclinical studies as a potential therapeutic agent. It is a biosimilar of the monoclonal antibody (mAb) tecaginlimab, which targets both CD40 and CD137, two important immune checkpoints that play a crucial role in regulating the immune response. In this article, we will discuss the structure, activity, and potential applications of Tecaginlimab Biosimilar. Structure of Tecaginlimab Biosimilar Tecaginlimab Biosimilar is a recombinant humanized monoclonal antibody, meaning that it is produced in a laboratory using genetic engineering techniques. It is composed of two heavy chains and two light chains, linked together by disulfide bonds. The heavy chains are made up of four constant regions (CH1, CH2, CH3, and CH4) and one variable region (VH), while the light chains consist of one constant region (CL) and one variable region (VL). The variable regions are responsible for binding to the target molecules, CD40 and CD137. Activity of Tecaginlimab Biosimilar CD40 and CD137 are both co-stimulatory molecules that are expressed on the surface of various immune cells, including T cells, B cells, and dendritic cells. These molecules play a critical role in activating and regulating the immune response. CD40 is involved in T cell activation, B cell differentiation, and cytokine production, while CD137 is involved in T cell proliferation and survival. Dysregulation of these pathways has been implicated in various autoimmune diseases and cancer. Tecaginlimab Biosimilar works by binding to both CD40 and CD137, blocking their interaction with their respective ligands and inhibiting their signaling pathways. This leads to a reduction in the activation and proliferation of immune cells, resulting in a dampened immune response. In addition, Tecaginlimab Biosimilar has been shown to induce antibody-dependent cell-mediated cytotoxicity (ADCC), where immune cells are activated to kill target cells that are bound by the antibody. Applications of Tecaginlimab Biosimilar The potential applications of Tecaginlimab Biosimilar are vast, given its ability to target two important immune checkpoints simultaneously. It has shown promising results in preclinical studies as a potential treatment for various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and psoriasis. By inhibiting the activation of immune cells, Tecaginlimab Biosimilar could potentially reduce the severity of these diseases and improve patient outcomes. In addition, Tecaginlimab Biosimilar has also shown potential as a cancer therapy. CD40 and CD137 have been identified as potential targets for cancer immunotherapy, and blocking their activity with Tecaginlimab Biosimilar could enhance the anti-tumor immune response. Preclinical studies have shown that Tecaginlimab Biosimilar can inhibit tumor growth and improve survival rates in animal models of cancer. Conclusion Tecaginlimab Biosimilar, a research grade antibody targeting both CD40 and CD137, has shown great potential as a therapeutic agent in preclinical studies. Its unique structure and mechanism of action make it a promising candidate for the treatment of various autoimmune diseases and cancer. Further research and clinical trials are needed to fully understand the potential of Tecaginlimab Biosimilar and its role in improving patient outcomes.

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx212409

CD40 Antibody is a Rabbit Polyclonal against CD40.

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx413221

CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibody is a Mouse Monoclonal antibody against CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40).

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx413215

CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibody is a Mouse Monoclonal antibody against CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40).

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx025477

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. This antibody is supplied as crude ascites.

ABflo® 647 Rabbit anti-Mouse CD40 mAb, ABclonal, A27176

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx270008

Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5) Antibody is a Rabbit Polyclonal Antibody against Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5) for use in flow cytometry.

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx000604

CD40 Antibody is a Rabbit Polyclonal antibody against CD40. This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody, Abbexa, abx013215

Rabbit polyclonal antibody against CD40 protein. Immunogen region is C-terminal.