Search results for db
mouse IKKB (pS701) Antibody, Abbexa, abx032257
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, DB
Conjugation
Unconjugated
ULK2 (pS323) Antibody, Abbexa, abx032215
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
TSC1 (pS682) Antibody, Abbexa, abx032264
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Claudin 2 (pY224) (CLDN2) Antibody, Abbexa, abx032057
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Nephrin (pY1193) Antibody, Abbexa, abx032101
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
KIT (pS959) Antibody, Abbexa, abx032205
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Caspase 3 Cleaved-Asp175 (CASP3 Cleaved-D175) Antibody, Abbexa, abx032087
Caspase 3 Cleaved-Asp175 (CASP3 Cleaved-D175) antibody is a Rabbit polyclonal against Caspase 3 (cleaved at Asp175). CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, DB
Conjugation
Unconjugated
YES1 pY537 / SRC pY530 Antibody, Abbexa, abx031917
YES1 pY537 / SRC pY530 Antibody is a Rabbit Polyclonal antibody against Tyrosine-Protein Kinase Yes Phospho-Tyr537 (YES1 pY537) / Proto-Oncogene Tyrosine-Protein Kinase Src Phospho-Tyr530 (SRC pY530). SRC has tyrosine kinase activity and belongs to the src family of proteins. The YES1 gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, DB
Conjugation
Unconjugated
Alpha Synuclein (SNCA) Antibody (Biotin), Abbexa, abx443089
Alpha Synuclein Antibody is a Mouse Monoclonal against Alpha Synuclein.
Host
Mouse
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, DB
Conjugation
Biotin
JMJD2A (pY547) Antibody, Abbexa, abx032088
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
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