Search results for class II
HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain (HLA-DPA1) Antibody, Abbexa, abx014529
Rabbit polyclonal antibody against HLA-DPA1 protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain (HLA-DPA1) Antibody, Abbexa, abx233902
HLA-DPA1 Antibody is a Rabbit Polyclonal against HLA-DPA1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Antibody (PE), Abbexa, abx270794
HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) for use in flow cytometry.
Host
Rabbit
Reactivity
Human
Applications
FCM
Conjugation
PE
HLA Class II Histocompatibility Antigen, DQ Alpha 2 Chain (HLA-DQA2) Antibody, Abbexa, abx109887
HLA class II histocompatibility antigen, DQ alpha 2 chain Antibody is a Rabbit Polyclonal antibody against HLA class II histocompatibility antigen, DQ alpha 2 chain.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Antibody (FITC), Abbexa, abx270330
HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Antibody (FITC) is a Rabbit Polyclonal Antibody conjugated to FITC against HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) for use in flow cytometry.
Host
Rabbit
Reactivity
Human
Applications
FCM
Conjugation
FITC
HLA Class II Histocompatibility Antigen, DR Beta 4 Chain (HLA-DRB4) Antibody, Abbexa, abx027539
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody (HRP), Abbexa, abx335997
HLA-DRB3 Antibody (HRP) is a Rabbit Polyclonal against HLA-DRB3.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
HLA Class II Histocompatibility Antigen, DQ Alpha 2 Chain (HLA-DQA2) Antibody, Abbexa, abx124334
HLA-DQA2 Antibody is a Rabbit Polyclonal Antibody against HLA-DQA2.
Host
Rabbit
Reactivity
Mouse, Rat
Applications
WB
Conjugation
Unconjugated
HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody, Abbexa, abx145237
HLA-DPB1 Antibody is a Rabbit Polyclonal against HLA-DPB1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain (HLA-DQB1) Antibody, Abbexa, abx034881
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
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