Search results for db

Anti-Neisseria meningitidis NadA/Neisseria adhesin A Antibody (G9), AntibodySystem, RXX13301

Anti-Neisseria meningitidis NadA/Neisseria adhesin A Antibody (F3), AntibodySystem, RXX13302

RAF1 (pS471) Antibody, Abbexa, abx031948

Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.

Bcl2-Associated Agonist of Cell Death Phospho-Ser109 (BAD pS109) Antibody, Abbexa, abx032132

Bad may be involved in induction of programmed cell death [RGD].

Microtubule-Associated Protein Tau (MAPT) Antibody (HRP), Abbexa, abx450173

Microtubule-Associated Protein Tau (MAPT) Antibody (HRP) is a Mouse Monoclonal against Microtubule-Associated Protein Tau (MAPT).

Bcl2-Associated Agonist of Cell Death Phospho-Tyr110 (BAD pY110) Antibody, Abbexa, abx032127

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq].

p27Kip1 (pS83) Antibody, Abbexa, abx032272

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Microtubule-Associated Protein Tau (MAPT) Antibody (HRP), Abbexa, abx451900

Microtubule-Associated Protein Tau (MAPT) Antibody (HRP) is a rabbit monoclonal antibody against Microtubule-Associated Protein Tau (MAPT). This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].

CSF2RB (pY766) Antibody, Abbexa, abx031871

CSF2RB (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.

BAD (pS96) Antibody, Abbexa, abx032255

BAD promotes cell death. Successfully competes for the binding to Bcl-X (L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X (L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.