Search results for Cadherin-1 (CDH1) Antibody
Cadherin-1 (CDH1) Antibody, Abbexa, abx002263
CDH1 Antibody is a Rabbit Polyclonal antibody against CDH1. Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. Cadherin-1 (E-Cad), also known as CDH1 and CD324, is the classical cadherin molecule and contains five cadherin domains of ~110 aa each in the extracellular domain. E-Cad is expressed in the non-neural epithelial tissues as disulfide-linked homodimer, and plays a key role in the organization and integrity of most epithelial tissues, cell differentiation and tissue development. CDH1 interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of Cadherin-1 expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas (gastric, breast, ovary, endometrium and thyroid).
Host
Mouse
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx101953
Polyclonal Antibody to Cadherin-1 (CDH1).
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx012163
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq].
Host
Mouse
Reactivity
Human, Mouse, Monkey
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx341083
Cadherin-1 (CDH1) Antibody is a Mouse Monoclonal antibody for the detection of Human CDH1.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx038132
Rabbit Polyclonal against the CDH1 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx101952
Polyclonal Antibody to Cadherin-1 (CDH1).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx341036
Cadherin-1 (CDH1) Antibody is a Mouse Monoclonal antibody for the detection of Human, Mouse CDH1.
Host
Mouse
Reactivity
Human, Mouse
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx241405
CDH1 Antibody is a Rabbit Polyclonal against CDH1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx101954
Polyclonal Antibody to Cadherin-1 (CDH1).
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Cadherin-1 (CDH1) Antibody, Abbexa, abx015807
Cadherin-1 is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins.In addition to being a calcium-dependent adhesion molecule, Cadherin-1 is also a critical regulator of epithelial junction formation.Its association with catenins is necessary for cell-cell adhesion.These Cadherin-1/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques.Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties.Cadherin-1 expression is often down-regulated in highly invasive, poorly differentiated carcinomas.Increased expression of Cadherin-1 in these cells reduces invasiveness.Thus, loss of expression or function of Cadherin-1 appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Host
Mouse
Reactivity
Human, Mouse, Monkey
Applications
ELISA, WB
Conjugation
Unconjugated
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