Search results for db
Alpha Synuclein (SNCA) Antibody (ATTO488), Abbexa, abx440554
Alpha Synuclein Antibody is a Mouse Monoclonal against Alpha Synuclein.
Host
Mouse
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, DB
Conjugation
ATTO488
Microtubule-Associated Protein Tau (MAPT) Antibody (ATTO390), Abbexa, abx451888
Microtubule-Associated Protein Tau (MAPT) Antibody (ATTO390) is a rabbit monoclonal antibody against Microtubule-Associated Protein Tau (MAPT). This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC, DB
Conjugation
ATTO390
Me2-H4 Antibody, Abbexa, abx032069
Histone proteins H3, H4, H2A, and H2B function as building blocks to package eukaryotic DNA into repeating nucleosome units that are folded in higher order chromatin fibers. The nucleosome is composed of an octamer containing a H3/H4 tetramer and two H2A/H2B dimers, surrounded by approximately 146 base pairs of DNA. A diverse and elaborate array of post-translational modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs on the N-terminal tail domains of histones.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM, DB
Conjugation
Unconjugated
MEK1 (pS222) Antibody, Abbexa, abx032048
MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, DB
Conjugation
Unconjugated
PHLPI (Pollen Allergen Phl P 1) Antibody, Abbexa, abx422455
Pollen Allergen Phl P 1 (PHLPI) Antibody is a Human Monoclonal against PHLPI.
Host
Human
Reactivity
Plant
Applications
DB, ELISA, SPR, WB
Conjugation
Unconjugated
Plasmodium falciparum Antibody, Abbexa, abx022135
Plasmodium falciparum Antibody is a Mouse monoclonal antibody for the detection of Plasmodium falciparum (Malaria) Histidine-Rich Protein 2 (HRP-2).
Host
Mouse
Reactivity
Protozoan
Applications
ELISA, WB, LF, DB
Conjugation
Unconjugated
IKKB (pS682) Antibody, Abbexa, abx032161
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
OCT4 (pS236) Antibody, Abbexa, abx032086
OCT4 encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t (6;22) (p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
MAP3K8 (pT290) Antibody, Abbexa, abx031973
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
PTEN (pT401) Antibody, Abbexa, abx032195
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
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