Search results for Protein kinase
Protein Kinase C Epsilon (PRKCE) Antibody, Abbexa, abx001722
PRKCE Antibody is a Rabbit Polyclonal antibody against PRKCE. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC
Conjugation
Unconjugated
Tyrosine-Protein Kinase TYRO10 (TYRO10) Antibody, Abbexa, abx033621
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Tyrosine-Protein Kinase Mer (MERTK) Antibody, Abbexa, abx432966
MERTK Antibody is a Goat Polyclonal antibody against MERTK.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB
Conjugation
Unconjugated
Protein Kinase Inhibitor Alpha (PKIA) Antibody, Abbexa, abx013552
Rabbit polyclonal antibody against IPKA protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Tyrosine-Protein Kinase Srms (SRMS) Antibody, Abbexa, abx033643
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Tyrosine-Protein Kinase JAK2 (JAK2) Antibody, Abbexa, abx326642
Tyrosine-Protein Kinase JAK2 (JAK2) Antibody is a Rabbit Polyclonal against Tyrosine-Protein Kinase JAK2 (JAK2).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Tau-Protein Kinase 1 (TPK1) Antibody, Abbexa, abx145300
TPK1 Antibody is a Rabbit Polyclonal against TPK1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Integrin-Linked Protein Kinase (ILK) Antibody, Abbexa, abx010989
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta 1 integrin.
Host
Mouse
Reactivity
Human, Mouse, Monkey
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Tyrosine-Protein Kinase BLK (BLK) Antibody, Abbexa, abx320332
BLK Antibody is a Rabbit Polyclonal against BLK.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Tyrosine-Protein Kinase HCK (HCK) Antibody, Abbexa, abx377461
Tyrosine-Protein Kinase HCK (HCK) Antibody is a Rabbit polyclonal antibody for the detection of Human Tyrosine-Protein Kinase HCK (HCK).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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