Search results for 6772

Signal Transducer And Activator of Transcription 1 (STAT1) Antibody, Abbexa, abx218784

Signal Transducer And Activator of Transcription 1 (STAT1) Antibody is a Rabbit Polyclonal antibody for the detection of STAT1. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Signal Transducer And Activator of Transcription 1 Phospho-Ser727 (STAT1 pS727) Antibody, Abbexa, abx139891

STAT1 (pS727) Antibody is a Mouse Monoclonal against STAT1 (pS727).

Signal Transducer and Activator of Transcription 1 (STAT1) Antibody, Abbexa, abx330098

STAT1 Antibody is a Rabbit Polyclonal against STAT1.

Signal Transducer And Activator of Transcription 1 Phospho-Tyr701 (STAT1 pY701) Antibody, Abbexa, abx000187

STAT1 (pY701) Antibody is a Rabbit Polyclonal antibody against STAT1 (pY701). Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

STAT1 antibody [SM1], Genetex, GTX23987

STAT1 (phospho Ser727) antibody [PSM1], Genetex, GTX23991

Signal Transducer And Activator of Transcription 1 (STAT1) Antibody, Abbexa, abx000529

STAT1 Antibody is a Rabbit Polyclonal antibody against STAT1. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Phospho-STAT1 (Ser727) Antibody (YA149)(PBS only), MedChemexpress, HY-P80855A

Phospho-STAT1 (Ser727) Antibody (YA149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT1 (Ser727).

Signal Transducer And Activator of Transcription 1 (STAT1) Antibody (FITC), Abbexa, abx305449

STAT1 Antibody (FITC) is a Rabbit Polyclonal against STAT1 conjugated to FITC.

Phospho-STAT1-S727 Rabbit mAb- ABclonal, ABclonal, AP1000