Search results for ADAM17

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx028424

ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (Biotin), Abbexa, abx272154

A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against A Disintegrin And Metalloprotease 17 (ADAM17).

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx037459

Rabbit Polyclonal against the ADAM17 protein.

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx230138

ADAM17 Antibody is a Rabbit Polyclonal against ADAM17.

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx028423

ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx000869

ADAM17 Antibody is a Rabbit Polyclonal antibody against ADAM17. The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

Anti-Human CD156b/ADAM17 Antibody (SAA2069), AntibodySystem, RHF68802

A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (PE), Abbexa, abx270907

A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (PE) is a Mouse Monoclonal Antibody conjugated to PE against A Disintegrin And Metalloprotease 17 (ADAM17) for use in flow cytometry.

ADAM Metallopeptidase Domain 17 (ADAM17) Antibody, Abbexa, abx430638

ADAM17 Antibody is a Goat Polyclonal antibody against ADAM17.

Anti-ADAM17 antibody [D1 (A12)] - BSA and Azide free, Abcam, AB215268

ADAM multidomain topology was exploited by first isolating an inhibitory human antibody (D1) that bound TACE-specific noncatalytic regions exclusively through its variable heavy (VH) domain. A D1-VH biased scFv phage-display library was then used to selectively isolate a new variable light (VL) chain that could simultaneously bind to the TACE catalytic domain. The resulting "cross-domain" human IgG1 antibody [D1(A12)] ab215268 is a previously undescribed biochemically holistic ADAM ectodomain inhibitor and demonstrates a unique alternative to small-molecule metalloprotease inhibition. Note from inventor: ab215268 is conformation sensitive and sees only a specific form of the native enzyme (reflecting its redox state). It does not work by IHC or WB. It was designed as a potential drug, active in native situations.