Search results for C3a
Complement Component 3a (C3a) Antibody, Abbexa, abx170588
Human Complement Component 3a (C3a) Antibody is a Mouse monoclonal against Complement Component 3a (C3a).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
C3/C3a, Human, mAb 2898, Hycult Biotech, HM2075
C3/C3a Abundant and Crucial in the Complement System C3, the most abundant protein in the complement system, plays a central role in innate immunity with serum levels approximately 1.3 mg/ml. As a critical component of the complement system, which includes three pathways, C3 and its fragment C3a are integral to both the classical, alternative, and lectin pathways of complement activation. The Activation and Function of C3/C3a The activation of C3 leads to the formation of various products, including C3a, which bear neo-epitopes absent in their native form. Monoclonal antibodies like the 2898 are instrumental in directly quantifying these activation stages. Tissue-specific synthesis of C3, responsive to numerous stimulants, further underscores the dynamic nature of C3/C3a in immune responses. Moreover, a deficiency in C3 can predispose individuals to frequent bacterial infections, emphasizing the protective role of C3/C3a in the immune system. This is particularly evident in conditions like ulcerative colitis and chronic inflammatory bowel disease, where abnormal C3 deposition is observed. Proteolytic Cleavage and the Stability of C3a Enzymatic proteolysis of C3 releases the anaphylatoxin C3a and C3b. The C3a fragment, a protein of 74 amino acids, is inherently short-lived, quickly transforming into the more stable form, C3a-desArg. This transformation makes C3a-desArg a reliable marker for complement activation levels in test samples, showcasing the significance of C3/C3a in immunological assays. C3a’s Role in Inflammatory Responses C3a is a potent mediator in local inflammatory processes. It induces smooth muscle contraction, increases vascular permeability, and triggers histamine release from mast cells and basophils. C3a mediates inflammation, impacting conditions like sepsis, ischemic heart disease, and autoimmune diseases. Conclusion The comprehensive understanding of C3/C3a, from its detection by monoclonal antibodies to its role in immune responses and diseases, is crucial. The study of C3/C3a not only illuminates key aspects of the immune system but also aids in the development of targeted therapeutic interventions. Not sure which C3 antibody to use? With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision: Go to our C3 researcher’s guide and choose the right antibody
Host
Human
Reactivity
Applications
Conjugation
C3/C3a, Human, mAb 474, Hycult Biotech, HM2073
Understanding Complement Protein C3/C3a and its Role in Innate Immunity The complement system, a crucial component of innate immunity, includes a pivotal element known as complement protein C3/C3a. This protein plays a central role in the classical, alternative, and lectin pathways of complement activation, underlining its importance in the immune response. The Synthesis and Function of Complement Protein C3/C3a Complement protein C3/C3a is synthesized in a tissue-specific manner, influenced by various stimulatory agents. A significant aspect of C3/C3a’s function involves its cleavage during complement activation. This cleavage releases C3a, an anaphylatoxic peptide consisting of 74 amino acids, approximately 10 kDa in size. C3a, known for its transient nature in serum, is quickly converted into a more stable form, C3a-desArg (also referred to as acylation stimulating protein, ASP). C3a’s Mechanism of Action C3a operates through a specific receptor, C3aR, belonging to the G-protein coupled receptor family. This receptor’s expression across various cell types, including myeloid and non-myeloid cells, underscores its broad impact. Notably, C3aR’s presence on hematopoietic stem/progenitor cells enhances their trafficking to the bone marrow. Additionally, C3aR’s engagement with dendritic cells (DCs) and T cells has been shown to augment their functions. C3a’s Role in Inflammatory Processes Complement protein C3/C3a, particularly C3a, is a key mediator in local inflammatory processes. It induces smooth muscle contraction, increases vascular permeability, and prompts histamine release from mast cells and basophilic leukocytes. The involvement of C3a in inflammatory responses is evident in conditions such as gram-negative bacterial sepsis, ischemic heart disease, and various autoimmune diseases. Not sure which C3 antibody to use? With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision: Go to our C3 researcher’s guide and choose the right antibody
Host
Human
Reactivity
Applications
Conjugation
C3a, Mouse, mAb 3/11, Hycult Biotech, HM1072
The monoclonal antibody 3/11 recognizes C3a, an activated fragment of the complement protein C3, a 190 kDa protein which is the most abundant complement protein in serum . C3 is the third component of the complement system and plays a central role in the complement cascade. The three pathways of compliment activation come together- at this key molecule. Cleavage of the pivotal complement component C3 results in the generation of a set of effector molecules which have diverse biological functions. The cleavage product C3b promotes complement acrtivation and the subsequent formation of the membrane attack complex. C3a, the small (ca. 10 kDa) cleavage product possesses anaphylatoxic as well as immunoregulatory- properties. It exerts its function through a specific receptor (C3aR), which belongs to the G-protein coupled receptor family. Expression of C3aR- has been reported in many cell types including myeloid and non-myeloid cells. Expression of C3aR on haematopoietic stem/progenitor cells has been shown to promote the trafficking/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions. The monoclonal antibody 3/11 reacts specifically with the C3a anaphylatoxin, providing a tool for monitoring acute complement activation (C3a generation) in experimental mouse models.
Host
Mouse
Reactivity
Applications
Conjugation
Complement Component 3a (C3a) Antibody, Abbexa, abx170591
Human Complement Component 3a (C3a) Antibody is a Mouse monoclonal against Complement Component 3a (C3a).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Complement Component 3a (C3a) Antibody, Abbexa, abx102217
Complement Component 3a (C3a) Antibody is a Rabbit polyclonal against Complement Component 3a (C3a).
Host
Rabbit
Reactivity
Rat
Applications
WB, IHC
Conjugation
Unconjugated
Complement Component 3a (C3a) Antibody, Abbexa, abx170590
Human Complement Component 3a (C3a) Antibody is a Mouse monoclonal against Complement Component 3a (C3a).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Complement Component 3a (C3a) Antibody, Abbexa, abx170595
Pig Complement Component 3a (C3a) Antibody is a Mouse monoclonal against Complement Component 3a (C3a).
Host
Mouse
Reactivity
Pig
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Complement Component 3a (C3a) Antibody, Abbexa, abx170592
Pig Complement Component 3a (C3a) Antibody is a Mouse monoclonal against Complement Component 3a (C3a).
Host
Mouse
Reactivity
Pig
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Complement Component 3a (C3a) Antibody, Abbexa, abx129946
Complement Component 3a Antibody is a Rabbit Polyclonal against Complement Component 3a.
Host
Rabbit
Reactivity
Pig
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
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