Search results for CD110

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx312919

MPL Antibody is a Rabbit Polyclonal against MPL.

Anti-CD110/MPL Antibody (R3K32), AntibodySystem, RHE26202

Anti-CD110/MPL Antibody (R3K33), AntibodySystem, RHE26203

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx327526

MPL Antibody is a Rabbit Polyclonal against MPL.

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx421013

Thrombopoietin Receptor / CD110 (MPL) Antibody is a Mouse Monoclonal antibody for the detection of Thrombopoietin Receptor / CD110 (MPL) in Human samples.

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx104172

Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL).

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx323336

MPL Antibody is a Rabbit Polyclonal against MPL.

Anti-CD110/MPL Antibody (R1V67), AntibodySystem, RHE26201

Thrombopoietin Receptor / CD110 (MPL) Antibody, Abbexa, abx011224

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Thrombopoietin Receptor / CD110 (MPL) Antibody (Biotin), Abbexa, abx312922

MPL Antibody (Biotin) is a Rabbit Polyclonal against MPL conjugated to Biotin.